Pam3CSK4
Tocris Bioscience, part of Bio-Techne | Catalog # 4633
TLR1/2 agonist; induces cytokine production
Key Product Details
Description
TLR1/2 agonist; induces cytokine production
Product Description
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.Product Specifications
Molecular Weight
1510.24
Formula
C81H156N10O13S
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
112208-00-1
PubChem ID
130704
InChI Key
OEDPHAKKZGDBEV-GFPBKZJXSA-N
SMILES
[H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 1mg/ml in 50% Ethanol / water |
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Background References
References are publications that support the biological activity of the product.
- Offermanns Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells. Biochem.J. 1992 PMID: 1312332
- Caproni MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action. J.Immunol. 2012 PMID: 22351935
- St Paul Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells. BMC Res.Notes 2012 PMID: 23116495
Product Specific Notices for Pam3CSK4
For research use only
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