Oxotremorine M
Tocris Bioscience, part of Bio-Techne | Catalog # 1067
Muscarinic agonist
Product Description
Oxotremorine M is a muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.Product Specifications
Molecular Weight
322.19
Formula
C11H19IN2O
Storage
Desiccate at -20°C
Purity
≥98% (HPLC)
Chemical Name
N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide
CAS Number
3854-04-4
PubChem ID
3027782
InChI Key
VVLMSCJCXMBGDI-UHFFFAOYSA-M
SMILES
O=C1N(CC#CC[N+](C)(C)C)CCC1.[I-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 32.22 | 100 |
Preparing Stock Solutions
for Oxotremorine M
The following data is based on the product molecular weight 322.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.10 mL | 15.52 mL | 31.04 mL |
| 5 mM | 0.62 mL | 3.10 mL | 6.21 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.10 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kukkonen Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system. J.Pharmacol.Exp.Ther. 1996 PMID: 8930161
- Zwart Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochem.Biophys.Res.Commun. 2017 PMID: 29127015
- Birdsall The binding of agonists to brain muscarinic receptors. Mol.Pharmacol. 1978 PMID: 714021
Product Specific Notices for Oxotremorine M
For research use only
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