Oxcarbazepine

Name: Oxcarbazepine
Brand: Tocris Bioscience
SKU: 3864
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3864

(1)

Citations (4)

COA / SDS

Anticonvulsant; inhibits Na+ channel activity

Key Product Details

Description:	Anticonvulsant; inhibits Na⁺ channel activity
Chemical Name:	10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	252.27

View Full Technical Details for Oxcarbazepine

Technical Data
Citations / Reviews (1)

Biological Activity for Oxcarbazepine

Oxcarbazepine is an anticonvulsant; protects mice and rats against generalized tonic-clonic seizures induced by electroshock. Thought to act via inhibition of sodium channel activity.

Technical Data for Oxcarbazepine

M. Wt	252.27
Formula	C₁₅H₁₂N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	28721-07-5
PubChem ID	34312
InChi Key	CTRLABGOLIVAIY-UHFFFAOYSA-N
Smiles	NC(N(C(C=CC=C3)=C3C2)C1=CC=CC=C1C2=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oxcarbazepine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	12.61	50

Preparing Stock Solutions for Oxcarbazepine

The following data is based on the product molecular weight 252.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.93 mL	39.64 mL	79.28 mL
2.5 mM	1.59 mL	7.93 mL	15.86 mL
5 mM	0.79 mL	3.96 mL	7.93 mL
25 mM	0.16 mL	0.79 mL	1.59 mL

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Reconstitution Calculator

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References for Oxcarbazepine

References are publications that support the biological activity of the product.

Ambrosio Mechanism of action of carbamaz. and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024. Neurochem.Res. 2002 PMID: 11926264
Zheng Oxcarbazepine, not its active metabolite, potentiates GABA_A activation and aggravates absence seizures. Epilepsia 2009 PMID: 18717705
Schmutz Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia 1994 PMID: 8039471