OSU 03012

Name: OSU 03012
Brand: Tocris Bioscience
SKU: 5682

Tocris Bioscience, part of Bio-Techne | Catalog # 5682

Citations (3)

COA / SDS

PDPK1 (PDK1) inhibitor; inhibits Akt signaling

Key Product Details

Description:	PDPK1 (PDK1) inhibitor; inhibits Akt signaling
Chemical Name:	2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	460.45

View Full Technical Details for OSU 03012

Technical Data
Citations

Biological Activity for OSU 03012

OSU 03012 is a PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro. Attenuates tumor growth of medulloblastoma xenografts in mice.

Compound Libraries for OSU 03012

OSU 03012 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for OSU 03012

M. Wt	460.45
Formula	C₂₆H₁₉F₃N₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	742112-33-0
PubChem ID	10027278
InChi Key	YULUCECVQOCQFQ-UHFFFAOYSA-N
Smiles	O=C(CN)NC(C=C1)=CC=C1N2C(C(C=C3)=CC4=C3C5=CC=CC=C5C=C4)=CC(C(F)(F)F)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OSU 03012

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.05	100

Preparing Stock Solutions for OSU 03012

The following data is based on the product molecular weight 460.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.86 mL	21.72 mL
5 mM	0.43 mL	2.17 mL	4.34 mL
10 mM	0.22 mL	1.09 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for OSU 03012

References are publications that support the biological activity of the product.

Yacoub OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Mol.Pharmacol. 2006 PMID: 16622074
Zhu From the cyclooxygenase-2 inhibitor cele. to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 2004 PMID: 15205346
Baryawno Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/β-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res. 2010 PMID: 20028853