Oseltamivir phosphate
Tocris Bioscience, part of Bio-Techne | Catalog # 7224
Influenza virus neuraminidase inhibitor; antiviral prodrug
Key Product Details
Description
Influenza virus neuraminidase inhibitor; antiviral prodrug
Alternative Names
GS 4104
Product Description
Oseltamivir phosphate is a viral neuraminidase inhibitor prodrug; metabolized to GS 4071. Metabolite exhibits potent inhibition of neuraminidase from multiple influenza strains (IC50 values range from 0.3 to 2 nM). Inhibits cellular effects of influenza infection in vitro (IC50 values range from 0.6 to 150 nM). Displays highest potency against H1N1 and H3N2 influenza A strains. Inhibits H1N1 influenza infection in mice.Product Specifications
Molecular Weight
410.40
Formula
C16H28N2O4.H3PO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl (3R,4R,5S)-4-Acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate phosphate
CAS Number
204255-11-8
PubChem ID
78000
InChI Key
PGZUMBJQJWIWGJ-ONAKXNSWSA-N
SMILES
O[P](O)(O)=O.CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.04 | 100 | |
| DMSO | 41.04 | 100 |
Preparing Stock Solutions
for Oseltamivir phosphate
The following data is based on the product molecular weight 410.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.18 mL | 24.37 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mendel Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob.Agents Chemother. 1998 PMID: 9517945
- Kim Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J.Am.Chem.Soc. 1997 PMID: 16526129
Product Specific Notices for Oseltamivir phosphate
For research use only
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