Org 20599

Name: Org 20599
Brand: Tocris Bioscience
SKU: 2738

Tocris Bioscience, part of Bio-Techne | Catalog # 2738

COA / SDS

Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations

Discontinued Product

2738 has been discontinued. View all GABA-A Receptor Modulators products.

Key Product Details

Description:	Positive allosteric modulator of GABA_A receptors; direct agonist at higher concentrations
Chemical Name:	(2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one
Molecular Weight:	438.04

View Full Technical Details for Org 20599

Technical Data
Citations

Biological Activity for Org 20599

Org 20599 is a positive allosteric modulator and at higher concentrations direct agonist of GABA_A receptors (EC₅₀ = 1.1 μM). Also displays positive modulation of glycine receptors (EC₅₀ = 22.9 μM). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Technical Data for Org 20599

M. Wt	438.04
Formula	C₂₅H₄₀ClNO₃
Storage	Store at RT
CAS Number	156685-94-8
PubChem ID	9850026
InChi Key	NZFNABGZEQPYBX-PMBZPZLSSA-N
Smiles	O=[C@](CCl)[C@H]4CC[C@@]3([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)[C@@H](N5CCOCC5)C[C@@](C)1[C@]([H])2CC[C@@]34C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Org 20599

References are publications that support the biological activity of the product.

Visser Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA_A receptor in vivo. J.Pharmacol.Exp.Ther. 2002 PMID: 12388643
Weir The interaction of anaesthetic steroids with recombinant glycine and GABA_A receptors. Br.J.Anaesth. 2004 PMID: 15033889
Hill-Venning The anaesthetic action and modulaton of GABA_A receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 1996 PMID: 9014136

Org 20599

Tocris Bioscience, part of Bio-Techne | Catalog # 2738

Key Product Details

Biological Activity for Org 20599

Technical Data for Org 20599

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Org 20599

Product Documents for Org 20599

COA

Certificate of Analysis

SDS

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