Ononetin
Tocris Bioscience, part of Bio-Techne | Catalog # 5143
TRPM3 blocker
Product Description
Ononetin is a naturally occurring deoxybenzoin. TRPM3 channel blocker (IC50 = 300 nM). Inhibits pregnenolone sulfate-induced intracellular Ca2+ accumulation in HEKmTRPM3 cells and dorsal root ganglia (DRG) neurons in vitro.Product Specifications
Molecular Weight
258.27
Formula
C15H14O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
CAS Number
487-49-0
PubChem ID
259632
InChI Key
XHBZOAYMBBUURD-UHFFFAOYSA-N
SMILES
COC1=CC=C(CC(C2=C(O)C=C(O)C=C2)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.83 | 100 | |
| Ethanol | 25.83 | 100 |
Preparing Stock Solutions
for Ononetin
The following data is based on the product molecular weight 258.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.87 mL | 19.36 mL | 38.72 mL |
| 5 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Straub Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br.J.Pharmacol. 2012 PMID: 23190005
Product Specific Notices for Ononetin
For research use only
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