ONO 1078

Tocris Bioscience, part of Bio-Techne | Catalog # 3026

Selective CysLT1 antagonist; also TREK2 activator
Discontinued Product
3026 has been discontinued. View all Leukotriene and Related Receptor Antagonists products.

Key Product Details

Description

Selective CysLT1 antagonist; also TREK2 activator

Alternative Names

Pranlukast

View all Leukotriene and Related Receptor Antagonists »

Product Description

ONO 1078 is a selective cysteinyl leukotriene receptor 1 (CysLT1) antagonist (IC50 values are ~ 4 - 7 and 3620 nM for CysLT1 and CysLT2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. Also TREK2 activator (pEC50 = 5.8); exhibits selectivity for TREK-2 over other K2P channels.

Product Specifications

Molecular Weight

481.50

Formula

C27H23N5O4

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide

CAS Number

103177-37-3

PubChem ID

4887

InChI Key

NBQKINXMPLXUET-UHFFFAOYSA-N

SMILES

O=C2C1=CC=CC(NC(C4=CC=C(OCCCCC5=CC=CC=C5)C=C4)=O)=C1OC(C3=NN=NN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.07 50

Preparing Stock Solutions for ONO 1078

The following data is based on the product molecular weight 481.50

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.15 mL 20.77 mL 41.54 mL
2.5 mM 0.83 mL 4.15 mL 8.31 mL
5 mM 0.42 mL 2.08 mL 4.15 mL
25 mM 0.08 mL 0.42 mL 0.83 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for ONO 1078

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ONO 1078

For research use only

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