ω-Agatoxin IVA

Name: ω-Agatoxin IVA
Brand: Tocris Bioscience
SKU: 2799
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2799

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Citations (10)

COA / SDS

CaV2.1 blocker

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

CaV2.1 blocker

Alternative Names

ω-Aga-IV A

View all Cav2.x Channel Blockers »

Product Description

ω-Agatoxin IVA is a selective blocker of P-type calcium channels (IC₅₀ < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.

Product Specifications

Molecular Weight

5202.25

Formula

C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

145017-83-0

PubChem ID

56841669

InChI Key

NVVFOMZVLALQKT-JYRRICCISA-N

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC5=CC=C(O)C=C5)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC5=C1C=CC=C5)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N4)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

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Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Tringham Protease treatment of cerebellar purkinje cells renders ω-agatoxin IVA-sensitive Ca²⁺ channels insensitive to inhibition by ω-conotoxin GVIA. J.Pharmacol.Exp.Ther. 2008 PMID: 17975010
Turner Calcium channels coupled to glutamate release identified by ω-Aga-IVA. Science 1992 PMID: 1357749
Bourinet Splicing of α_1A subunit gene generates phenotypic variants of P- and Q-type calcium channels. Nat.Neurosci. 1999 PMID: 10321243
Mintz P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature 1992 PMID: 1311418