OLDA

Name: OLDA
Brand: Tocris Bioscience
SKU: 1641

Tocris Bioscience, part of Bio-Techne | Catalog # 1641

Citations (10)

COA / SDS

Potent and selective endogenous TRPV1 agonist

Key Product Details

Description:	Potent and selective endogenous TRPV1 agonist
Alternative Names:	N-Oleoyldopamine
Chemical Name:	(9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide
Purity:	≥98% (HPLC)
Molecular Weight:	417.63

View Full Technical Details for OLDA

Technical Data
Citations

Biological Activity for OLDA

OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC₅₀ = 36 nM at hVR1) with low affinity for rCB₁ receptors (K_i = 1.6 μM). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo.

Technical Data for OLDA

M. Wt	417.63
Formula	C₂₆H₄₃NO₃
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	105955-11-1
PubChem ID	5282106
InChi Key	QQBPLXNESPTPNU-KTKRTIGZSA-N
Smiles	CCCCCCCC\C=C/CCCCCCCC(=O)NCCC1=CC=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OLDA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.88	50
	ethanol	20.88	50

Preparing Stock Solutions for OLDA

The following data is based on the product molecular weight 417.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.79 mL	23.94 mL	47.89 mL
2.5 mM	0.96 mL	4.79 mL	9.58 mL
5 mM	0.48 mL	2.39 mL	4.79 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

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References for OLDA

References are publications that support the biological activity of the product.

Chu N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 2003 PMID: 12569099
Butelman Anitallodynic effects of loperamide and fen. against topical capsaicin-induced allodynia in unanesthetized primates. J.Pharmacol.Exp.Ther. 2004 PMID: 15152028