Okadaic acid ammonium salt

Name: Okadaic acid ammonium salt
Brand: Tocris Bioscience
SKU: 9012

Tocris Bioscience, part of Bio-Techne | Catalog # 9012

COA / SDS

Protein phosphatase 1 and 2A inhibitor

Key Product Details

Description:	Protein phosphatase 1 and 2A inhibitor
Chemical Name:	9,10-Deepithio-9,10-didehydroacanthifolicin ammonium salt
Purity:	≥98% (HPLC)
Molecular Weight:	822.04

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Technical Data
Citations

Biological Activity for Okadaic acid ammonium salt

Okadaic acid ammonium salt is a potent inhibitor of protein phosphatase 1 (IC₅₀ = 3 nM) and protein phosphatase 2A (IC₅₀ = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Technical Data for Okadaic acid ammonium salt

M. Wt	822.04
Formula	C₄₄H₆₇O₁₃.NH₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	175522-42-6
PubChem ID	162640608
InChi Key	ZBOMSHVRJSJGNR-GHIYGBLASA-N
Smiles	C[C@H]([C@H]1O[C@]2(OCCCC2)CC[C@H]1C)C[C@H](O)[C@@](C([C@H]3O)=C)([H])O[C@@](CC4)([H])[C@@]3([H])O[C@@]54CC[C@H](/C=C/[C@@H](C)[C@H](CC(C)=C6)O[C@@]76O[C@H](C[C@](O)(C)C([O-])=O)CC[C@H]7O)O5.[NH4+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Okadaic acid ammonium salt

References are publications that support the biological activity of the product.

Deng Molecular dynamic simulation on the synergistic corrosion inhibition effect and mechanism of quinoline quaternary ammonium salt and L-methionine. Chem.Technol.Fuels.Oils
Nuydens Okadaic acid-induced apopstosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998 PMID: 9489733
Haystead Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 1989 PMID: 2562908
McCluskey Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem 2002 PMID: 11881984
Cohen Okadaic acid: a new probe for the study of cellular regulation. TiBS 1990 PMID: 2158158

Okadaic acid ammonium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 9012

Key Product Details

Biological Activity for Okadaic acid ammonium salt

Technical Data for Okadaic acid ammonium salt

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Okadaic acid ammonium salt

Product Documents for Okadaic acid ammonium salt

COA

Certificate of Analysis

SDS

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