O8 OGG1 Inhibitor
Tocris Bioscience, part of Bio-Techne | Catalog # 6236
Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Key Product Details
Description
Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor
Product Description
O8 OGG1 Inhibitor is a potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.Product Specifications
Molecular Weight
261.13
Formula
C9H6Cl2N2OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
CAS Number
350997-39-6
PubChem ID
874733
InChI Key
HSSHUDKWJRJKPV-UHFFFAOYSA-N
SMILES
NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.11 | 100 |
Preparing Stock Solutions
for O8 OGG1 Inhibitor
The following data is based on the product molecular weight 261.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.15 mL | 38.30 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.66 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Donley Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1). ACS Chem.Biol. 2015 PMID: 26218629
Product Specific Notices for O8 OGG1 Inhibitor
For research use only
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