O-1602

Tocris Bioscience, part of Bio-Techne | Catalog # 2797

(2)

Citations (50)

COA / SDS

Potent GPR55 agonist

Key Product Details

Description:	Potent GPR55 agonist
Chemical Name:	5-Methyl-4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol
Purity:	≥97% (HPLC)
Molecular Weight:	258.36

View Full Technical Details for O-1602

Technical Data
Citations / Reviews (2)

Biological Activity for O-1602

O-1602 is an analog of cannabidiol that is a potent agonist at the GPR55 cannabinoid receptor (EC₅₀ values are 13, > 30000 and > 30000 nM for GPR55, CB₁ and CB₂ receptors respectively). Induces activation of RhoA, cdc42 and rac1. Increases proliferation of neural stem cells NSCs in vitro and in vivo. Also promotes neurogenesis in vivo.

Technical Data for O-1602

M. Wt	258.36
Formula	C₁₇H₂₂O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	317321-41-8
PubChem ID	45073499
InChi Key	KDZOUSULXZNDJH-LSDHHAIUSA-N
Smiles	C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(O)C=C2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for O-1602

Solubility

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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References for O-1602

References are publications that support the biological activity of the product.

Johns The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects. Br.J.Pharmacol. 2007 PMID: 17704827
Hill Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br.J.Pharmacol. 2018 PMID: 29888782
Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302