NVP-TNKS656

Name: NVP-TNKS656
Brand: Tocris Bioscience
SKU: 8913

Tocris Bioscience, part of Bio-Techne | Catalog # 8913

COA / SDS

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells

Key Product Details

Description:	Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
Chemical Name:	N-(Cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]-1-piperidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	494.58

View Full Technical Details for NVP-TNKS656

Technical Data
Citations

Biological Activity for NVP-TNKS656

NVP-TNKS656 is a potent inhibitor of tankyrase enzymes (pIC₅₀ values are 7.8 and 8.2 for TNSK1 and TNKS2 respectively). It displays >5000 selectivity over PARP1 and PARP2. In vivo, it disrupts Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. NVP-TNKS656 is used to generate neurons from epiblast stem cells. NVP-TNKS656 is orally bioavailable.

Technical Data for NVP-TNKS656

M. Wt	494.58
Formula	C₂₇H₃₄N₄O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1419949-20-4
PubChem ID	136237316
InChi Key	DYGBNAYFDZEYBA-UHFFFAOYSA-N
Smiles	O=C1N=C(NC2=C1COCC2)CN(C(=O)CN3CCC(C(=O)C4=CC=C(OC)C=C4)CC3)CC5CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVP-TNKS656

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.95	10

Preparing Stock Solutions for NVP-TNKS656

The following data is based on the product molecular weight 494.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.22 mL	101.10 mL	202.19 mL
0.5 mM	4.04 mL	20.22 mL	40.44 mL
1 mM	2.02 mL	10.11 mL	20.22 mL
5 mM	0.40 mL	2.02 mL	4.04 mL

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References for NVP-TNKS656

References are publications that support the biological activity of the product.

Shultz Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor. J.Med.Chem. 2013 PMID: 23844574
Medina-Cano A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro. Dev.Cell 2025 PMID: 40876454