NTRC 824

Name: NTRC 824
Brand: Tocris Bioscience
SKU: 5438

Tocris Bioscience, part of Bio-Techne | Catalog # 5438

Citations (17)

COA / SDS

Potent and selective non-peptide NTS2 antagonist

Key Product Details

Description:	Potent and selective non-peptide NTS₂ antagonist
Chemical Name:	N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine
Purity:	≥98% (HPLC)
Molecular Weight:	553.55

View Full Technical Details for NTRC 824

Technical Data
Citations

Biological Activity for NTRC 824

NTRC 824 is a potent and selective non-peptide neurotensin (NTS) type-2 receptor antagonist (IC₅₀ = 38 nM). Exhibits >150-fold selectivity for NTS₂ over NTS₁.

Compound Libraries for NTRC 824

NTRC 824 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NTRC 824

M. Wt	553.55
Formula	C₂₅H₂₆F₃N₃O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1623002-61-8
PubChem ID	101873359
InChi Key	SOOLLEBJNGCDOZ-FQEVSTJZSA-N
Smiles	O=C(C(F)(F)F)C2=CN(CC(N[C@@H](CC(C)C)C(O)=O)=O)C1=CC=C(NS(C3=CC=C(C)C=C3)(=O)=O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NTRC 824

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	55.35	100
	ethanol	55.35	100

Preparing Stock Solutions for NTRC 824

The following data is based on the product molecular weight 553.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.03 mL	18.07 mL
5 mM	0.36 mL	1.81 mL	3.61 mL
10 mM	0.18 mL	0.90 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for NTRC 824

References are publications that support the biological activity of the product.

Thomas Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-L-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J.Med.Chem. 2014 PMID: 25157640