NTNCB hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2155
Potent and selective non-peptidic NPY Y5 antagonist
Discontinued Product
2155 has been discontinued.
View all NPY Receptor Antagonists products.
Key Product Details
Description
Potent and selective non-peptidic NPY Y5 antagonist
Product Description
NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Potently antagonizes NPY inhibition of forskolin-stimulated cAMP. Displays some affinity for cloned human D2 and α2C receptors (Ki values are 63 and 100 nM respectively).Product Specifications
Molecular Weight
508.07
Formula
C25H33N3O4S.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-Nitro-N-[[trans-4-[[[(1,2,3,4-tetrahydro-2-naphthalenyl)methyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide hydrochloride
CAS Number
191931-56-3
PubChem ID
124081021
InChI Key
BKCQHNDMUNWNQC-GMIOCVINSA-N
SMILES
O=S(NC[C@@H](CC3)CC[C@H]3CNCC2CCC1=CC=CC=C1C2)(C4=C([N+]([O-])=O)C=CC=C4)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.81 | 100 |
Preparing Stock Solutions
for NTNCB hydrochloride
The following data is based on the product molecular weight 508.07
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.84 mL | 19.68 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.20 mL | 0.98 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Islam Discovery of potent and selective small molecule NPY Y5 receptor antagonists. Bioorg.Med.Chem.Lett. 2002 PMID: 12067557
Product Specific Notices for NTNCB hydrochloride
For research use only
Loading...
Loading...