NSC 74859

Name: NSC 74859
Brand: Tocris Bioscience
SKU: 4655

Tocris Bioscience, part of Bio-Techne | Catalog # 4655

Citations (12)

COA / SDS

Selective STAT3 inhibitor

Key Product Details

Description:	Selective STAT3 inhibitor
Alternative Names:	S3I-201
Chemical Name:	2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	365.36

View Full Technical Details for NSC 74859

Technical Data
Citations

Biological Activity for NSC 74859

NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC₅₀ values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

Compound Libraries for NSC 74859

NSC 74859 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NSC 74859

M. Wt	365.36
Formula	C₁₆H₁₅NO₇S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	501919-59-1
PubChem ID	252682
InChi Key	HWNUSGNZBAISFM-UHFFFAOYSA-N
Smiles	CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NSC 74859

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.54	100

Preparing Stock Solutions for NSC 74859

The following data is based on the product molecular weight 365.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.69 mL	27.37 mL
5 mM	0.55 mL	2.74 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for NSC 74859

References are publications that support the biological activity of the product.

Siddiquee Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17463090
Lin The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 2009 PMID: 19137011