NSC 74859
Tocris Bioscience, part of Bio-Techne | Catalog # 4655
Selective STAT3 inhibitor
Key Product Details
Description
Selective STAT3 inhibitor
Alternative Names
S3I-201
Product Description
NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.Product Specifications
Molecular Weight
365.36
Formula
C16H15NO7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid
CAS Number
501919-59-1
PubChem ID
252682
InChI Key
HWNUSGNZBAISFM-UHFFFAOYSA-N
SMILES
CC1=CC=C(S(OCC(NC2=CC=C(C(O)=O)C(O)=C2)=O)(=O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.54 | 100 |
Preparing Stock Solutions
for NSC 74859
The following data is based on the product molecular weight 365.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.69 mL | 27.37 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Siddiquee Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 2007 PMID: 17463090
- Lin The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene 2009 PMID: 19137011
Product Specific Notices for NSC 74859
For research use only
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