NSC 687852

Name: NSC 687852
Brand: Tocris Bioscience
SKU: 4566

Tocris Bioscience, part of Bio-Techne | Catalog # 4566

COA / SDS

Inhibitor of UCHL5 and USP14

Discontinued Product

4566 has been discontinued. View all Deubiquitinating Enzyme Inhibitors products.

Key Product Details

Description:	Inhibitor of UCHL5 and USP14
Alternative Names:	b-AP15
Chemical Name:	3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
Purity:	≥97% (HPLC)
Molecular Weight:	419.39

View Full Technical Details for NSC 687852

Technical Data
Citations

Biological Activity for NSC 687852

NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC₅₀ = 0.5 μM). Displays antitumor activity in vivo.

Technical Data for NSC 687852

M. Wt	419.39
Formula	C₂₂H₁₇N₃O₆
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	1009817-63-3
PubChem ID	5351435
InChi Key	GFARQYQBWJLZMW-JYFOCSDGSA-N
Smiles	O=C(/C(CN(C(C=C)=O)C3)=C/C2=CC=C([N+]([O-])=O)C=C2)/C3=C/C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NSC 687852

References are publications that support the biological activity of the product.

D'Arcy Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat.Med. 2011 PMID: 22057347
Berndtsson Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int.J.Cancer 2009 PMID: 19089926

NSC 687852

Tocris Bioscience, part of Bio-Techne | Catalog # 4566

Key Product Details

Biological Activity for NSC 687852

Technical Data for NSC 687852

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NSC 687852

Product Documents for NSC 687852

COA

Certificate of Analysis

SDS

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