NS 5806

Tocris Bioscience, part of Bio-Techne | Catalog # 4166

KV4.3 channel activator
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Key Product Details

Description

KV4.3 channel activator

View all Voltage-gated Potassium Channel Activators »

Product Description

NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito). Increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM). Inhibits KV1.4-mediated currents independently of KChIP2. Also slows the decay of KV4.2 and KV4.3 currents in the presence of KChIP2.

Product Specifications

Molecular Weight

574.07

Formula

C16H8Br2F6N6O

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea

CAS Number

426834-69-7

PubChem ID

11642685

InChI Key

UZWJWROOLOOCPQ-UHFFFAOYSA-N

SMILES

BrC1=CC(Br)=CC(C2=NN=NN2)=C1NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.41 100
Ethanol 28.7 50

Preparing Stock Solutions for NS 5806

The following data is based on the product molecular weight 574.07

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.71 mL 17.42 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 5806

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 5806

For research use only

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