NS 398
Tocris Bioscience, part of Bio-Techne | Catalog # 0942
Cyclooxygenase-2 (COX-2) inhibitor
Key Product Details
Description
Cyclooxygenase-2 (COX-2) inhibitor
Product Description
NS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.Product Specifications
Molecular Weight
314.36
Formula
C13H18N2O5S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
CAS Number
123653-11-2
PubChem ID
4553
InChI Key
KTDZCOWXCWUPEO-UHFFFAOYSA-N
SMILES
CS(=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.44 | 100 |
Preparing Stock Solutions
for NS 398
The following data is based on the product molecular weight 314.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.18 mL | 15.91 mL | 31.81 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
| 10 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Futaki NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen.Pharmacol. 1993 PMID: 8482483
- Futaki NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994 PMID: 8140262
- Elder The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int.J.Cancer 2002 PMID: 11992399
Product Specific Notices for NS 398
For research use only
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