NS 3861
Tocris Bioscience, part of Bio-Techne | Catalog # 4831
α3β2 full agonist; also α3β4 partial agonist
Key Product Details
Description
α3β2 full agonist; also α3β4 partial agonist
Product Description
NS 3861 is a α3β2 full agonist (EC50 = 1.6 μM). Also α3β4 partial agonist (EC50 = 1 μM). Exhibits minimal activity at α4β2 and α4β4. Displays high affinity for α3β4, α4β4, α3β2 and α4β2 (Ki values are 0.62, 7.8, 25 and 55 nM respectively).Product Specifications
Molecular Weight
400.29
Formula
C12H14BrNS.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate
CAS Number
216853-60-0
PubChem ID
91826078
InChI Key
KXBSQPLWTVQFGJ-WLHGVMLRSA-N
SMILES
CN1C2CCC1CC(C3=C(Br)C=CS3)=C2.OC(/C=C/C(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 20.01 | 50 | |
| DMSO | 40.03 | 100 |
Preparing Stock Solutions
for NS 3861
The following data is based on the product molecular weight 400.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.49 mL | 24.98 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.00 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harpsøe Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. J.Biol.Chem. 2013 PMID: 23229547
Product Specific Notices for NS 3861
For research use only
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