NS 3728

Tocris Bioscience, part of Bio-Techne | Catalog # 6973

VRAC blocker
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Key Product Details

Description

VRAC blocker

Alternative Names

Endovion

View all Other Chloride Channel Blockers »

Product Description

NS 3728 is a volume-regulated anion channel (VRAC) blocker (IC50 = 460 nM). Blocks red blood cell chloride conductance (IC50 = 0.6 μM). NS 3728 also inhibits Ca2+-activated Cl- current (CaCC) by anoctamin (ANO) in an apparently voltage-dependent manner (IC50 against ANO1 = 2.1 and 0.7 μM at -95 and +50 mV, respectively).

Product Specifications

Molecular Weight

495.18

Formula

C16H9BrF6N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[3,5-bis(Trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]urea

CAS Number

265646-85-3

PubChem ID

10005966

InChI Key

AEFYFGMSRKDXHZ-UHFFFAOYSA-N

SMILES

FC(F)(C1=CC(C(F)(F)F)=CC(NC(NC2=C(C3=NN=NN3)C=C(C=C2)Br)=O)=C1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.52 100
Ethanol 24.76 50

Preparing Stock Solutions for NS 3728

The following data is based on the product molecular weight 495.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.10 mL 20.19 mL
5 mM 0.40 mL 2.02 mL 4.04 mL
10 mM 0.20 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 3728

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 3728

For research use only

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