NS 3623

Name: NS 3623
Brand: Tocris Bioscience
SKU: 4462
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4462

(1)

Citations (2)

COA / SDS

KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic

Key Product Details

Description:	K_V11.1 (hERG) and K_V4.3 channel activator; antiarrhythmic
Chemical Name:	N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Purity:	≥99% (HPLC)
Molecular Weight:	427.18

View Full Technical Details for NS 3623

Technical Data
Citations / Reviews (1)

Biological Activity for NS 3623

NS 3623 is a K_V11.1 (hERG) and K_V4.3 channel activator. Activates the I_Kr and I_to currents and displays antiarrhythmic activity. May also act as a partial blocker of K_V11.1 channels. Displays selectivity over the key cardiac potassium channels, K_V7.1 (KCNQ1) and K_V1.5. Suitable for both in vitro and in vivo use.

Compound Libraries for NS 3623

NS 3623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 3623

M. Wt	427.18
Formula	C₁₅H₁₀BrF₃N₆O
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	343630-41-1
PubChem ID	9954236
InChi Key	JXPULDIATMTIIN-UHFFFAOYSA-N
Smiles	BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 3623

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.72	100

Preparing Stock Solutions for NS 3623

The following data is based on the product molecular weight 427.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.70 mL	23.41 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for NS 3623

References are publications that support the biological activity of the product.

Calloe A dual potassium channel activator improves repolarization reserve and normalizes ventricular action potentials. Biochem.Pharmacol. 2016 PMID: 27002181
George Restoring repolarization in LQT3. Heart Rhythm. 2009 PMID: 19121809
Hansen Pharmacological activation of rapid delayed rectifier potassium current suppresses bradycardia-induced triggered activity in the isolated guinea pig heart. J.Pharmacol.Exp.Ther. 2007 PMID: 17325228
Hansen Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]. Mol.Pharmacol. 2006 PMID: 16825484