NS 19504

Product Description

NS 19504 is a selective activator of large-conductance Ca²⁺-activated potassium channels (BK_Ca, K_Ca1.1) (EC₅₀ = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K⁺ concentration or at 65 other receptors tested, including L- and N- type Ca²⁺ channels, Na_v, K_ATP and hERG channels.

Solubility

Preparing Stock Solutions for NS 19504

The following data is based on the product molecular weight 269.16

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.72 mL	18.58 mL	37.15 mL
5 mM	0.74 mL	3.72 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.72 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nausch NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 2014 PMID: 24951278