NPS 2143 hydrochloride

Name: NPS 2143 hydrochloride
Brand: Tocris Bioscience
SKU: 3626

Tocris Bioscience, part of Bio-Techne | Catalog # 3626

Citations (18)

COA / SDS

Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent

Key Product Details

Description:	Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
Chemical Name:	2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrile hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	445.38

View Full Technical Details for NPS 2143 hydrochloride

Technical Data
Citations

Biological Activity for NPS 2143 hydrochloride

NPS 2143 hydrochloride is a selective Ca²⁺-sensing receptor antagonist. Blocks increases in cytoplasmic Ca²⁺ concentrations elicited by human Ca²⁺ receptors expressed in HEK293 cells (IC₅₀ = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC₅₀ = 41 nM). Orally active calcilytic compound.

Compound Libraries for NPS 2143 hydrochloride

NPS 2143 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NPS 2143 hydrochloride

M. Wt	445.38
Formula	C₂₄H₂₅ClN₂O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	324523-20-8
PubChem ID	9868131
InChi Key	ZEBNDUQLNGYBNL-VEIFNGETSA-N
Smiles	CC(NC[C@@H](O)COC3=C(C#N)C(Cl)=CC=C3)(C)CC2=CC1=CC=CC=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NPS 2143 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.54	100
	ethanol	4.45	10

Preparing Stock Solutions for NPS 2143 hydrochloride

The following data is based on the product molecular weight 445.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.23 mL	22.45 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for NPS 2143 hydrochloride

References are publications that support the biological activity of the product.

Nemeth The search for calcium receptor antagonists (calcilytics). J.Mol.Endocrinol. 2002 PMID: 12200226
Huang and Breitwieser Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis. J.Biol.Chem. 2007 PMID: 17284438
Nemeth Calcilytic compounds: potent and selective Ca²⁺ receptor antagonists that stimulate secretion of parathyroid hormone. J.Pharmacol.Exp.Ther. 2001 PMID: 11561095