NNC 55-0396 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2268
Highly selective CaV3.x blocker
Product Description
NNC 55-0396 dihydrochloride is a highly selective T-type calcium channel blocker. Displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.Product Specifications
Molecular Weight
564.57
Formula
C30H38FN3O2.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl cyclopropanecarboxylate dihydrochloride
CAS Number
357400-13-6
PubChem ID
22084904
InChI Key
BCCQNBXHUMKLFW-HNQRYHMESA-N
SMILES
FC1=CC(CC[C@@](CCN(C)CCCC3=NC(C=CC=C5)=C5N3)(OC(C4CC4)=O)[C@H]2[C@H](C)C)=C2C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.11 | 25 |
Preparing Stock Solutions
for NNC 55-0396 dihydrochloride
The following data is based on the product molecular weight 564.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.09 mL | 35.43 mL | 70.85 mL |
| 1.25 mM | 1.42 mL | 7.09 mL | 14.17 mL |
| 2.5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 12.5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chen CaV3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. J.Neurosci. 2010 PMID: 20685979
- Huang NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A new selective inhibitor of T-type calcium cha J.Pharmacol.Exp.Ther. 2004 PMID: 14718587
Product Specific Notices for NNC 55-0396 dihydrochloride
For research use only
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