NNC 26-9100
Tocris Bioscience, part of Bio-Techne | Catalog # 2440
Selective sst4 agonist
Product Description
NNC 26-9100 is a somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).Product Specifications
Molecular Weight
556.35
Formula
C22H25N6Cl2SBr
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
CAS Number
199522-35-5
PubChem ID
9893924
InChI Key
UREJDUPKGMFJRU-UHFFFAOYSA-N
SMILES
ClC1=C(Cl)C=C(CN(CCCNC(=S)NCCCC2=CNC=N2)C2=CC=C(Br)C=N2)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.82 | 50 | |
| Ethanol | 27.82 | 50 |
Preparing Stock Solutions
for NNC 26-9100
The following data is based on the product molecular weight 556.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.59 mL | 17.97 mL | 35.95 mL |
| 2.5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 5 mM | 0.36 mL | 1.80 mL | 3.59 mL |
| 25 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liu 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. Curr.Pharm.Des. 1999 PMID: 10101224
- Liu Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J.Med.Chem. 1998 PMID: 9822540
Product Specific Notices for NNC 26-9100
For research use only
Loading...
Loading...