NK 252

Name: NK 252
Brand: Tocris Bioscience
SKU: 5293

Tocris Bioscience, part of Bio-Techne | Catalog # 5293

Citations (1)

COA / SDS

Nrf2 activator

Key Product Details

Description:	Nrf2 activator
Chemical Name:	N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N'-(2-pyridinylmethyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	285.26

View Full Technical Details for NK 252

Technical Data
Citations

Biological Activity for NK 252

NK 252 is an Nrf2 activator; interacts with the Nrf2-binding site of Keap1. Downregulates the expression of fibrogenic genes and increases antioxidant effects in NASH rat models of liver disease.

Compound Libraries for NK 252

NK 252 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NK 252

M. Wt	285.26
Formula	C₁₃H₁₁N₅O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1414963-82-8
PubChem ID	71618700
InChi Key	FNSCFQXZZNCDAI-UHFFFAOYSA-N
Smiles	O=C(NC2=NN=C(C3=CC=CO3)O2)NCC1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NK 252

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	28.53	100
	DMSO	28.53	100

Preparing Stock Solutions for NK 252

The following data is based on the product molecular weight 285.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.51 mL	17.53 mL	35.06 mL
5 mM	0.70 mL	3.51 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.51 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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References for NK 252

References are publications that support the biological activity of the product.

Shimozono Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol.Pharmacol. 2013 PMID: 23592516