Nitazoxanide
Tocris Bioscience, part of Bio-Techne | Catalog # 7234
Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
Key Product Details
Description
Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
Product Description
Nitazoxanide is a pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC50 = 2.12μM).Product Specifications
Molecular Weight
307.28
Formula
C12H9N3O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
CAS Number
55981-09-4
PubChem ID
41684
InChI Key
YQNQNVDNTFHQSW-UHFFFAOYSA-N
SMILES
CC(OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.73 | 100 |
Preparing Stock Solutions
for Nitazoxanide
The following data is based on the product molecular weight 307.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.54 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 PMID: 32020029
- Qu Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat.Chem.Biol. 2017 PMID: 29083417
- Shakya Update on Nitazoxanide: a multifunctional chemotherapeutic agent. Curr.Drug Discov.Technol. 2018 PMID: 28748751
Product Specific Notices for Nitazoxanide
For research use only
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