Nitazoxanide

Name: Nitazoxanide
Brand: Tocris Bioscience
SKU: 7234

Tocris Bioscience, part of Bio-Techne | Catalog # 7234

COA / SDS

Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective

Key Product Details

Description:	Pyruvate flavodoxin/ferredoxin oxidoreductase inhibitor; also inhibits Wnt signaling; broad spectrum anti-infective
Chemical Name:	2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	307.28

View Full Technical Details for Nitazoxanide

Technical Data
Citations

Biological Activity for Nitazoxanide

Nitazoxanide is a pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor. Also inhibits Wnt signaling by stabilization of peptidyl arginine deiminase 2 (PAD2). Broad-spectrum antiparasitic and antiviral. Inhibits SARS-CoV-2 infection in Vero E6 cells (EC₅₀ = 2.12μM).

Compound Libraries for Nitazoxanide

Nitazoxanide is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Nitazoxanide

M. Wt	307.28
Formula	C₁₂H₉N₃O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	55981-09-4
PubChem ID	41684
InChi Key	YQNQNVDNTFHQSW-UHFFFAOYSA-N
Smiles	CC(OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nitazoxanide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.73	100

Preparing Stock Solutions for Nitazoxanide

The following data is based on the product molecular weight 307.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.27 mL	32.54 mL
5 mM	0.65 mL	3.25 mL	6.51 mL
10 mM	0.33 mL	1.63 mL	3.25 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Molarity Calculator

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Reconstitution Calculator

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References for Nitazoxanide

References are publications that support the biological activity of the product.

Wang Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 PMID: 32020029
Qu Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat.Chem.Biol. 2017 PMID: 29083417
Shakya Update on Nitazoxanide: a multifunctional chemotherapeutic agent. Curr.Drug Discov.Technol. 2018 PMID: 28748751