Nintedanib
Tocris Bioscience, part of Bio-Techne | Catalog # 7049
Potent VEGFR, PDGFR and FGFR inhibitor
Key Product Details
Description
Potent VEGFR, PDGFR and FGFR inhibitor
Product Description
Nintedanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) (IC50 values are 13 - 34 nM for VEGFR subtypes, 59 - 65 nM for PDGFR subtypes, 37 - 108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC50 values are 25 - 200 nM). Inhibits proliferation in VEGF-stimulated endothelial cells, and PDGF-stimulated pericytes and vascular smooth muscle cells. Reduces vessel density and integrity, and inhibits tumor growth in a mouse tumor xenograft model.Product Specifications
Molecular Weight
539.64
Formula
C31H33N5O4
Storage
Store at -20°C
Purity
≥98%
Chemical Name
Methyl (Z)-3-[[[4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene]-2-oxoindoline-6-carboxylate
CAS Number
656247-17-5
PubChem ID
135423438
InChI Key
XZXHXSATPCNXJR-ZIADKAODSA-N
SMILES
COC(=O)C1=CC=C2C(NC(=O)\C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.08 | 2 with gentle warming |
Preparing Stock Solutions
for Nintedanib
The following data is based on the product molecular weight 539.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.02 mM | 92.65 mL | 463.27 mL | 926.54 mL |
| 0.1 mM | 18.53 mL | 92.65 mL | 185.31 mL |
| 0.2 mM | 9.27 mL | 46.33 mL | 92.65 mL |
| 1 mM | 1.85 mL | 9.27 mL | 18.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hilberg BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 PMID: 18559524
Product Specific Notices for Nintedanib
For research use only
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