Nilutamide

Name: Nilutamide
Brand: Tocris Bioscience
SKU: 1759

Tocris Bioscience, part of Bio-Techne | Catalog # 1759

COA / SDS

Androgen receptor antagonist. Orally active

Discontinued Product

1759 has been discontinued. View all Androgen Receptor Antagonists products.

Key Product Details

Description:	Androgen receptor antagonist. Orally active
Alternative Names:	RU 23908
Chemical Name:	5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Purity:	≥99% (HPLC)
Molecular Weight:	317.22

View Full Technical Details for Nilutamide

Technical Data
Citations

Biological Activity for Nilutamide

Non-steroidal and silent antiandrogen. Binds to androgen receptors and also inhibits androgen biosynthesis in vitro. In rats in vivo it inhibits androgen-induced prostate weight increase and inhibits negative androgen-dependent gonadotropin feedback leading to an increase in luteinising hormone and testosterone. Orally active.

Technical Data for Nilutamide

M. Wt	317.22
Formula	C₁₂H₁₀F₃N₃O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	63612-50-0
PubChem ID	4493
InChi Key	XWXYUMMDTVBTOU-UHFFFAOYSA-N
Smiles	CC1(C)NC(=O)N(C1=O)C1=CC=C(C(=C1)C(F)(F)F)N(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Nilutamide

References are publications that support the biological activity of the product.

Raynaud Pharmacology and clinical studies with RU 23908 (Anandron). Prog.Clin.Biol.Res. 1985 PMID: 4034583
Raynaud Action of a non-steroid anti-androgen, RU 23908, in peripheral and central tissues. J.Steroid Biochem. 1979 PMID: 385986
Raynaud The pure antiandrogen RU 23908 (Anandron), a candidate of choice for the combined antihormonal treatment of prostatic cancer. The Prostate 1984 PMID: 6374639
Ayub and Levell Inhibition of rat testicular 17-α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J.Steroid Biochem. 1987 PMID: 2956461

Nilutamide

Tocris Bioscience, part of Bio-Techne | Catalog # 1759

Key Product Details

Biological Activity for Nilutamide

Technical Data for Nilutamide

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Nilutamide

Product Documents for Nilutamide

COA

Certificate of Analysis

SDS

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