NIKi
Tocris Bioscience, part of Bio-Techne | Catalog # 7136
Potent NIK inhibitor
Product Description
NIKi is a potent inhibitor of NF-κB-inducing kinase (NIK) activity (IC50 = 20 nM).Product Specifications
Molecular Weight
366.42
Formula
C20H22N4O3
Storage
Store at -20°C
Purity
≥98%
Chemical Name
4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol
CAS Number
1202763-91-4
PubChem ID
58221375
InChI Key
ZZIZLABGKZWVAW-UHFFFAOYSA-N
SMILES
COCCOC1=CN=C(N=C1C2=CNC3=CC=C(C#CC(C)(O)C)C=C23)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.64 | 100 |
Preparing Stock Solutions
for NIKi
The following data is based on the product molecular weight 366.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg.Med.Chem.Lett. 2013 PMID: 23374866
Product Specific Notices for NIKi
For research use only
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