Nelfinavir mesylate

Name: Nelfinavir mesylate
Brand: Tocris Bioscience
SKU: 3766

Tocris Bioscience, part of Bio-Techne | Catalog # 3766

Citations (2)

COA / SDS

Potent HIV-1 protease inhibitor

Key Product Details

Description:	Potent HIV-1 protease inhibitor
Alternative Names:	AG 1341
Chemical Name:	(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	663.89

View Full Technical Details for Nelfinavir mesylate

Technical Data
Citations

Biological Activity for Nelfinavir mesylate

Nelfinavir mesylate is an orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K_i = 2 nM) in vitro. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC₅₀ = 0.08 μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Nelfinavir mesylate

M. Wt	663.89
Formula	C₃₂H₄₅N₃O₄S.CH₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	159989-65-8
PubChem ID	64142
InChi Key	NQHXCOAXSHGTIA-SKXNDZRYSA-N
Smiles	[H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nelfinavir mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	66.39	100
	ethanol	66.39	100

Preparing Stock Solutions for Nelfinavir mesylate

The following data is based on the product molecular weight 663.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.51 mL	7.53 mL	15.06 mL
5 mM	0.30 mL	1.51 mL	3.01 mL
10 mM	0.15 mL	0.75 mL	1.51 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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References for Nelfinavir mesylate

References are publications that support the biological activity of the product.

Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 2021 PMID: 33918958
Musarrat The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J.Med.Virol. 2020 PMID: 32374457
Patick Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 1996 PMID: 8787874
Gills Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res.
Shetty Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 1996 PMID: 8787890