Nefiracetam
Tocris Bioscience, part of Bio-Techne | Catalog # 2851
Cognitive enhancer
Key Product Details
Description
Cognitive enhancer
Alternative Names
DM 9384
Product Description
Nefiracetam is a cognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.Product Specifications
Molecular Weight
246.30
Formula
C14H18N2O2
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-(2,6-Dimethylphenyl)-2-oxo-1-pyrrolidineacetamide
CAS Number
77191-36-7
PubChem ID
71157
InChI Key
NGHTXZCKLWZPGK-UHFFFAOYSA-N
SMILES
O=C(NC2=C(C)C=CC=C2C)CN1C(CCC1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.63 | 100 | |
| Ethanol | 24.63 | 100 |
Preparing Stock Solutions
for Nefiracetam
The following data is based on the product molecular weight 246.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.06 mL | 20.30 mL | 40.60 mL |
| 5 mM | 0.81 mL | 4.06 mL | 8.12 mL |
| 10 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ueda The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 2004 PMID: 14718588
- Kitano Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 2005 PMID: 16190926
- Narahashi Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 2004 PMID: 15516710
Product Specific Notices for Nefiracetam
For research use only
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