Necrosulfonamide
Tocris Bioscience, part of Bio-Techne | Catalog # 5025
Necroptosis inhibitor; also inhibits pyroptosis
Key Product Details
Description
Necroptosis inhibitor; also inhibits pyroptosis
Product Description
Necrosulfonamide is a necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.Product Specifications
Molecular Weight
461.47
Formula
C18H15N5O6S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
CAS Number
1360614-48-7
PubChem ID
1566236
InChI Key
FNPPHVLYVGMZMZ-XBXARRHUSA-N
SMILES
O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.23 | 20 |
Preparing Stock Solutions
for Necrosulfonamide
The following data is based on the product molecular weight 461.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.83 mL | 54.17 mL | 108.35 mL |
| 1 mM | 2.17 mL | 10.83 mL | 21.67 mL |
| 2 mM | 1.08 mL | 5.42 mL | 10.83 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pandeya Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 2019 PMID: 31191857
- Sun Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012 PMID: 22265413
- Kreuzaler Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 2012 PMID: 22576162
- Zhou New components of the necroptotic pathway. Protein Cell 2012 PMID: 23073834
Product Specific Notices for Necrosulfonamide
For research use only
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