NECA

Tocris Bioscience, part of Bio-Techne | Catalog # 1691

High affinity adenosine agonist
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Key Product Details

Description

High affinity adenosine agonist

Alternative Names

5'-N-Ethylcarboxamidoadenosine

View all Non-selective Adenosine Receptor Agonists »

Product Description

NECA is a high affinity adenosine receptor agonist (Ki values are 6.2, 14, and 20 nM for human A3, A1 and A2A receptors respectively; EC50 = 2.4 μM for human A2B). Inhibits platelet aggregation and is centrally active in vivo.

Product Specifications

Molecular Weight

308.30

Formula

C12H16N6O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide

CAS Number

35920-39-9

PubChem ID

448222

InChI Key

JADDQZYHOWSFJD-FLNNQWSLSA-N

SMILES

O[C@@H]1[C@@H]([C@](NCC)=O)O[C@@H](N2C=NC3=C2N=CN=C3N)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.33 40

Preparing Stock Solutions for NECA

The following data is based on the product molecular weight 308.30

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.4 mM 8.11 mL 40.54 mL 81.09 mL
2 mM 1.62 mL 8.11 mL 16.22 mL
4 mM 0.81 mL 4.05 mL 8.11 mL
20 mM 0.16 mL 0.81 mL 1.62 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for NECA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NECA

For research use only

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