NE 100 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3133
Selective σ1 antagonist
Product Description
NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.Product Specifications
Molecular Weight
391.97
Formula
C23H33NO2.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
CAS Number
149409-57-4
PubChem ID
9952420
InChI Key
ZHGMDXSHODHWHV-UHFFFAOYSA-N
SMILES
CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.96 | 5 | |
| DMSO | 39.2 | 100 |
Preparing Stock Solutions
for NE 100 hydrochloride
The following data is based on the product molecular weight 391.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.76 mL | 25.51 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Okuyama NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts.
- Tanaka Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol.
- Chaki NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain. Eur.J.Pharmacol. 1994 PMID: 8137864
Product Specific Notices for NE 100 hydrochloride
For research use only
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