NCT 501 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5934
Potent and selective ALDH1A1 inhibitor
Key Product Details
Description
Potent and selective ALDH1A1 inhibitor
Product Description
NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable.Product Specifications
Molecular Weight
452.98
Formula
C21H32N6O3.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)-1H-purine-2,6-dione hydrochloride
CAS Number
2080306-22-3
PubChem ID
124201852
InChI Key
MQNBJYUQFQUJQZ-UHFFFAOYSA-N
SMILES
CC(CCN1C(CN2CCN(C(C3CC3)=O)CC2)=NC4=C1C(N(C(N4C)=O)C)=O)C.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.3 | 100 | |
| DMSO | 45.3 | 100 |
Preparing Stock Solutions
for NCT 501 hydrochloride
The following data is based on the product molecular weight 452.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.04 mL | 22.08 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Discovery of NCT-501, a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1). J.Med.Chem. 2015 PMID: 26207746
Product Specific Notices for NCT 501 hydrochloride
For research use only
Loading...
Loading...