NBMPR

Name: NBMPR
Brand: Tocris Bioscience
SKU: 2924
Rating: 0 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2924

(1)

Citations (22)

COA / SDS

Equilibrative nucleoside transporter 1 (ENT1) inhibitor

Key Product Details

Description:	Equilibrative nucleoside transporter 1 (ENT1) inhibitor
Chemical Name:	6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
Purity:	≥98% (HPLC)
Molecular Weight:	419.41

View Full Technical Details for NBMPR

Technical Data
Citations / Reviews (1)

Biological Activity for NBMPR

NBMPR is an equilibrative nucleoside transporter 1 (ENT1) inhibitor (K_i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Compound Libraries for NBMPR

NBMPR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBMPR

M. Wt	419.41
Formula	C₁₇H₁₇N₅O₆S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	38048-32-7
PubChem ID	65407
InChi Key	DYCJFJRCWPVDHY-LSCFUAHRSA-N
Smiles	OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3SCC4=CC=C([N+]([O-])=O)C=C4)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBMPR

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.94	100

Preparing Stock Solutions for NBMPR

The following data is based on the product molecular weight 419.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for NBMPR

References are publications that support the biological activity of the product.

Tsujie Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 PMID: 17695509
Lin and Buolamwini Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 2007 PMID: 17636949
Ward Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 2000 PMID: 10722669