NBI 31772
Tocris Bioscience, part of Bio-Techne | Catalog # 5192
High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
Key Product Details
Description
High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
Product Description
NBI 31772 is a high affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo.Product Specifications
Molecular Weight
341.27
Formula
C17H11NO7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
CAS Number
374620-70-9
PubChem ID
54684689
InChI Key
QUIWTBSOEFPLHE-FOCLMDBBSA-N
SMILES
O=C(C3=CC=C(O)C(O)=C3)C2=NC(C(O)=O)=CC1=CC(O)=C(O)C=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.13 | 100 |
Preparing Stock Solutions
for NBI 31772
The following data is based on the product molecular weight 341.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.93 mL | 14.65 mL | 29.30 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.93 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Choi In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 2013 PMID: 23293297
- Chen Discovery of a series of nonpeptide small molecules that inhibit the binding of Ins-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 2001 PMID: 11689087
Product Specific Notices for NBI 31772
For research use only
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