NAV 26
Tocris Bioscience, part of Bio-Techne | Catalog # 4691
Selective Nav1.7 channel blocker
Discontinued Product
4691 has been discontinued.
View all Voltage-gated Sodium Channel Blockers products.
Key Product Details
Description
Selective Nav1.7 channel blocker
Product Description
NAV 26 is a selective Nav1.7 channel blocker (IC50 = 370 nM). Exhibits >85-fold selectivity for Nav1.7 over Nav1.5 and hERG channels. Reduces nociceptive behavior in rat models of pain.Product Specifications
Molecular Weight
434.41
Formula
C22H21F3N2O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindole-1-carboxamide
CAS Number
1198160-14-3
PubChem ID
44540282
InChI Key
ICGMZCVSHDKQTE-UHFFFAOYSA-N
SMILES
O=C2C1=CC=CC=C1C(C(NCC4=CC=C(OC(F)(F)F)C=C4)=O)N2C3CCOCC3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.44 | 100 | |
| Ethanol | 21.72 | 50 |
Preparing Stock Solutions
for NAV 26
The following data is based on the product molecular weight 434.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.51 mL | 23.02 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Macsari 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7 with efficacy in rat pain models. J.Med.Chem. 2012 PMID: 22770500
Product Specific Notices for NAV 26
For research use only
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