Naspm trihydrochloride is a selective antagonist of Ca²⁺-permeable AMPA receptors; blocks AMPA receptors lacking the GluA2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.

Product Specifications

Molecular Weight

479.91

Formula

C₂₂H₃₄N₄O.3HCl

Storage

Desiccate at +4°C

Purity

≥97% (HPLC)

Chemical Name

N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride

CAS Number

1049731-36-3

PubChem ID

16219727

InChI Key

JNEOJAUJWOPWJS-UHFFFAOYSA-N

SMILES

O=C(NCCCNCCCCNCCCN)CC2=CC=CC1=CC=CC=C12.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	47.99	100

Preparing Stock Solutions for Naspm trihydrochloride

The following data is based on the product molecular weight 479.91

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Background References

References are publications that support the biological activity of the product.

Noh Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death. Proc.Natl.Acad.Sci.USA
Koike Blocking effect of 1-naphthyl acetyl spermine on Ca²⁺-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci.Res. 1997 PMID: 9293490
Nilsen and England A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc. 2007 PMID: 17391037
Tsubokawa Effects of spider toxin and its analogue on glutamate-activated currents in the hippocampal CA1 neuron after ischaemia. J.Neurophysiol. 1995 PMID: 7472325

Naspm trihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2766

Key Product Details

Description

Alternative Names

View all AMPA Receptor Antagonists »

Product Description