NAN-190 hydrobromide

Name: NAN-190 hydrobromide
Brand: Tocris Bioscience
SKU: 0553

Tocris Bioscience, part of Bio-Techne | Catalog # 0553

Citations (8)

COA / SDS

5-HT1A antagonist

Key Product Details

Description:	5-HT_1A antagonist
Chemical Name:	1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	474.4

View Full Technical Details for NAN-190 hydrobromide

Technical Data
Citations

Biological Activity for NAN-190 hydrobromide

NAN-190 hydrobromide is a 5-HT_1A antagonist.

Technical Data for NAN-190 hydrobromide

M. Wt	474.4
Formula	C₂₃H₂₇N₃O₃.HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	115338-32-4
PubChem ID	107966
InChi Key	AXRUEPFPTQYHQD-UHFFFAOYSA-N
Smiles	Br.COC1=C(C=CC=C1)N1CCN(CCCCN2C(=O)C3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NAN-190 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.74	10

Preparing Stock Solutions for NAN-190 hydrobromide

The following data is based on the product molecular weight 474.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.08 mL	105.40 mL	210.79 mL
0.5 mM	4.22 mL	21.08 mL	42.16 mL
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

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References for NAN-190 hydrobromide

References are publications that support the biological activity of the product.

Glennon Arylpiperazine derivatives as high affinity 5-HT_1A serotonin ligands. J.Med.Chem. 1988 PMID: 3172131
Williams and Glennon NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT_1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur.J.Pharmacol. 1988 PMID: 2976673
Douris Effects of the putative 5-HT_1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT_1A receptor agonist 8-OH-DPAT in the rat. Eur.J.Pharmacol. 1992 PMID: 1397037