Naltrexone hydrochloride

Name: Naltrexone hydrochloride
Brand: Tocris Bioscience
SKU: 0677

Tocris Bioscience, part of Bio-Techne | Catalog # 0677

Citations (33)

COA / SDS

Non-selective opioid antagonist

Key Product Details

Description:	Non-selective opioid antagonist
Chemical Name:	(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	377.87

View Full Technical Details for Naltrexone hydrochloride

Technical Data
Citations

Biological Activity for Naltrexone hydrochloride

Naltrexone hydrochloride is an opioid antagonist.

Technical Data for Naltrexone hydrochloride

M. Wt	377.87
Formula	C₂₀H₂₃NO₄.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	16676-29-2
PubChem ID	11957643
InChi Key	RHBRMCOKKKZVRY-ITLPAZOVSA-N
Smiles	Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Naltrexone hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	37.79	100

Preparing Stock Solutions for Naltrexone hydrochloride

The following data is based on the product molecular weight 377.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.23 mL	26.46 mL
5 mM	0.53 mL	2.65 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for Naltrexone hydrochloride

References are publications that support the biological activity of the product.

Tempel Supersensitivity of brain opiate receptor subtypes after chronic naltr. treatment. Life Sci. 1982 PMID: 6292636
Zukin Naltrexone-induced opiate receptor supersensitivity. Brain Res. 1982 PMID: 6289965
Gold Naltrexone, opiate addiction, and endorphins. Med.Res.Rev. 1982 PMID: 6289026