Naloxone hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0599
Non-selective opioid antagonist
Key Product Details
Description
Non-selective opioid antagonist
Product Description
Naloxone hydrochloride is an opioid antagonist.Product Specifications
Molecular Weight
363.84
Formula
C19H21NO4.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one hydrochloride
CAS Number
357-08-4
PubChem ID
5464092
InChI Key
RGPDIGOSVORSAK-STHHAXOLSA-N
SMILES
Cl.[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC=C)CC[C@@]14[C@@]5(O)CCC2=O)=CC=C3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 36.38 | 100 |
Preparing Stock Solutions
for Naloxone hydrochloride
The following data is based on the product molecular weight 363.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Spivak Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid cavity. Mol.Pharmacol. 1997 PMID: 9415708
- Olson Endogenous opiates: 1995. Peptides
- Pinelli and Trivulzio Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with mor. and injected with naloxone, in the absence or presence of the antiabstinence agent clon. J.Pharmacol.Toxicol.Methods 1997 PMID: 9523765
Product Specific Notices for Naloxone hydrochloride
For research use only
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