NAADP tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 3905
Ca2+ mobilizing agent
Key Product Details
Description
Ca2+ mobilizing agent
Alternative Names
NAADP
Product Description
NAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.Product Specifications
Molecular Weight
832.32
Formula
C21H23N6Na4O18P3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
PubChem ID
90488897
InChI Key
NWKIGVGTZIAOCW-MCNGMCCKSA-J
SMILES
[Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 41.62 | 50 |
Preparing Stock Solutions
for NAADP tetrasodium salt
The following data is based on the product molecular weight 832.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.40 mL | 12.01 mL | 24.03 mL |
| 2.5 mM | 0.48 mL | 2.40 mL | 4.81 mL |
| 5 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 25 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dammerman NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci.
- Galion NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions
- Calcraft NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 2009 PMID: 19387438
Product Specific Notices for NAADP tetrasodium salt
For research use only
Loading...
Loading...