N6-Cyclopentyladenosine
Tocris Bioscience, part of Bio-Techne | Catalog # 1702
Potent and selective A1 agonist
Key Product Details
Description
Potent and selective A1 agonist
Alternative Names
CPA
Product Description
N6-Cyclopentyladenosine is a potent and selective adenosine A1 receptor agonist (Ki values are 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively; EC50 = 18600 nM for hA2B). Centrally active following systemic administration in vivo.Product Specifications
Molecular Weight
335.36
Formula
C15H21N5O4
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-Cyclopentyladenosine
CAS Number
41552-82-3
PubChem ID
657378
InChI Key
SQMWSBKSHWARHU-SDBHATRESA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCC3)=NC=N2)[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 33.54 | 100 |
Preparing Stock Solutions
for N6-Cyclopentyladenosine
The following data is based on the product molecular weight 335.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.60 mL | 2.98 mL | 5.96 mL |
| 10 mM | 0.30 mL | 1.49 mL | 2.98 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Klotz Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch.Pharmacol. 2000 PMID: 11111832
- Van der Graaf Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9353402
- Coffin and Spealman Behavioral and cardiovascular effects of analogs of adenosine in Cynomolgus monkeys. J.Pharmacol.Exp.Ther. 1987 PMID: 3572798
Product Specific Notices for N6-Cyclopentyladenosine
For research use only
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