N6-Cyclohexyladenosine
Tocris Bioscience, part of Bio-Techne | Catalog # 6863
High affinity A1 receptor agonist
Discontinued Product
6863 has been discontinued.
View all Adenosine A1 Receptor Agonists products.
Key Product Details
Description
High affinity A1 receptor agonist
Product Description
N6-Cyclohexyladenosine is a high affinity adenosine A1 receptor agonist (Kd values are 0.7 and 6 nM for bovine and guinea pig brain membranes, respectively). Reduces light-induced circadian phase delays. Exhibits protective effect in lysolecithin-induced demyelination model. When administered prior to ischemia, improves functional recovery of heart in a mouse model of ischemia-reperfusion injury. Induces hypothermia following icv administration in mice.Product Specifications
Molecular Weight
349.38
Formula
C16H23N5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclohexyladenosine
CAS Number
36396-99-3
PubChem ID
9841284
InChI Key
SZBULDQSDUXAPJ-XNIJJKJLSA-N
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(NC3CCCCC3)N=CN=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.94 | 100 | |
| Ethanol | 6.99 | 20 |
Preparing Stock Solutions
for N6-Cyclohexyladenosine
The following data is based on the product molecular weight 349.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.31 mL | 28.62 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Futatsuki Involvement of orexin neurons in fasting- and central adenosine-induced hypothermia. Sci.Rep. 2018 PMID: 29426934
- Shao Adenosine A1 receptor activation increases myocardial protein S-nitrosothiols and elicits protection from ischemia-reperfusion injury in male and female hearts. PLoS One 2017 PMID: 28493997
- Sigworth and Rea Adenosine A1 receptors regulate the response of the mouse circadian clock to light. Brain Res. 2003 PMID: 12505678
- Asghari Adenosine A1 receptor agonist, N6-cyclohexyladenosine, protects myelin and induces remyelination in an experimental model of rat optic chiasm demyelination; electrophysiological and histopathological studies. J.Neurol.Sci. 2013 PMID: 23260322
- Bruns Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine. Proc.Natl.Acad.Sci.U.S.A. 1980 PMID: 6254090
Product Specific Notices for N6-Cyclohexyladenosine
For research use only
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