N-Nonyldeoxynojirimycin
Tocris Bioscience, part of Bio-Techne | Catalog # 3691
Glucosidase inhibitor
Key Product Details
Description
Glucosidase inhibitor
Alternative Names
NN-DNJ
Product Description
N-Nonyldeoxynojirimycin is a glucosidase inhibitor (IC50 values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.Product Specifications
Molecular Weight
289.41
Formula
C15H31NO4
Storage
Store at -20°C
Chemical Name
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
CAS Number
81117-35-3
PubChem ID
501640
InChI Key
FTSCEGKYKXESFF-LXTVHRRPSA-N
SMILES
O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.94 | 100 | |
| Ethanol | 28.94 | 100 |
Preparing Stock Solutions
for N-Nonyldeoxynojirimycin
The following data is based on the product molecular weight 289.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.46 mL | 17.28 mL | 34.55 mL |
| 5 mM | 0.69 mL | 3.46 mL | 6.91 mL |
| 10 mM | 0.35 mL | 1.73 mL | 3.46 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mellor Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 2004 PMID: 15128289
- Sawkar Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA
- Andersson Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 2004 PMID: 14757169
Product Specific Notices for N-Nonyldeoxynojirimycin
For research use only
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