MYX 1715

Name: MYX 1715
Brand: Tocris Bioscience
SKU: 8109

Tocris Bioscience, part of Bio-Techne | Catalog # 8109

COA / SDS

N-myristoyltransferase (NMT) inhibitor

Key Product Details

Description:	N-myristoyltransferase (NMT) inhibitor
Chemical Name:	4-[2-[2-[3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	553.91

View Full Technical Details for MYX 1715

Technical Data
Citations

Biological Activity for MYX 1715

MYX 1715 is a N-myristoyltransferase inhibitor (NMT). MYX 1715 selectively kills senescent cancer cells in mouse models of paediatric pituitary tumors and liver cancer, and prevents tumor growth in mouse xenografts. In mouse models of idiopathic pulmonary fibrosis (IPF) and NASH, MYX 1715 reduces both lung and liver fibrosis, and decreases inflammation and steatosis.

Technical Data for MYX 1715

M. Wt	553.91
Formula	C₂₅H₂₉ClN₆O₂.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	IPOQBMAKZNXYNK-UHFFFAOYSA-N
Smiles	O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MYX 1715

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	55.39	100
	water	55.39	100

Preparing Stock Solutions for MYX 1715

The following data is based on the product molecular weight 553.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.03 mL	18.05 mL
5 mM	0.36 mL	1.81 mL	3.61 mL
10 mM	0.18 mL	0.90 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for MYX 1715

References are publications that support the biological activity of the product.

McHugh COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. Nat.Cell Biol. 2023 PMID: 38012402